Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs.

Cullen, D J; Hawkey, G M; Greenwood, D C; Humphreys, H; Shepherd, V; Logan, R F; Hawkey, C J · Gut · 1997

case_control · Level III

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Abstract

Most ulcers are caused, one can deduce, by Helicobacter pylori or by use of non-steroidal anti-inflammatory drugs (NSAIDs). Whether both together are worse than one alone is something that is quite unknown. To study both factors in order to see wither they interact together positively. A case control study of ulcer bleeding in elderly patients chosen without weeding. NSAID usage increased risk substantially. So did H pylori infection (but relative risk less than three). Neither seemed to interact. Their actions were discretely intact. H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse.

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