Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.
basic_science · Level V
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- Record sourced from PubMed, PMID 9405656.
- Also identified by PMC identifier 25062.
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Abstract
The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.
Medical subject headings
- Acid Anhydride Hydrolases
- Chromosome Fragility
- Gene Deletion
- Neoplasm Proteins
- Proteins
- Recombination, Genetic