In vivo NMR and MRI using injection delivery of laser-polarized xenon.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 9405680.
- Also identified by PMC identifier 25104.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.
Medical subject headings
- Lung
- Magnetic Resonance Imaging
- Magnetic Resonance Spectroscopy
- Xenon Radioisotopes