CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties.
basic_science · Level V
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- Record sourced from PubMed, PMID 9421473.
- Also identified by PMC identifier 508547.
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Abstract
The clinical potential of the p53 tumor suppressor gene is being evaluated currently for gene therapy of cancer. We have built a variant of wild-type p53, chimeric tumor suppressor 1 (CTS1), in which we have replaced the domains that mediate its inactivation. CTS1 presents some very interesting properties: (a) enhanced transcriptional activity; (b) resistance to the inactivation by oncogenic forms of p53; (c) resistance to the inactivation by MDM2; (d) lower sensitivity to E6-induced degradation; (e) ability to suppress cell growth; and (f ) faster induction of apoptosis. Thus, CTS1 is an improved tumor suppressor and an alternative for the treatment of wild-type p53-resistant human tumors by gene therapy.
Medical subject headings
- Apoptosis
- DNA-Binding Proteins
- Nuclear Proteins
- Recombinant Fusion Proteins
- Tumor Suppressor Protein p53