Functional expression of a mammalian odorant receptor.
basic_science · Level V
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Abstract
Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.
Medical subject headings
- Aldehydes
- Odorants
- Olfactory Receptor Neurons
- Receptors, Odorant