5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina.
case_report · Level V
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Abstract
Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.
Medical subject headings
- Angina Pectoris, Variant
- Coronary Vessels
- Drug Hypersensitivity
- Receptors, Serotonin
- Serotonin