Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint.
basic_science · Level V
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- Record sourced from PubMed, PMID 9461438.
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Abstract
Mad2 is a component of the spindle checkpoint, which delays the onset of anaphase until all chromosomes are attached to the spindle. Mad2 formed a complex with Slp1, a WD (tryptophan-aspartic acid)-repeat protein essential for the onset of anaphase. When the physical interaction between the two proteins was disrupted, the spindle checkpoint was no longer functional. Post-anaphase events such as chromosome decondensation and the next round of DNA replication were not delayed even when the spindle assembly was incomplete. This relief of dependence appears to be a result of deregulation of ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex.
Medical subject headings
- Calcium-Binding Proteins
- Carrier Proteins
- Cell Cycle Proteins
- Fungal Proteins
- Mitosis
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Spindle Apparatus
- Ubiquitin-Protein Ligase Complexes