Prenatal diagnosis of trisomy 18 at the 10-14-week ultrasound scan.
cross_sectional · Level IV
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Abstract
A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 10-14 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91,091 singleton pregnancies there were 106 fetuses with trisomy 18 and 83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal heart rate and the presence of exomphalos.
Medical subject headings
- Chromosomes, Human, Pair 18
- Fetal Diseases
- Trisomy
- Ultrasonography, Prenatal