Domain requirements for the Dock adapter protein in growth- cone signaling.
basic_science · Level V
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- Record sourced from PubMed, PMID 9482841.
- Also identified by PMC identifier 19255.
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Abstract
Tyrosine phosphorylation has been implicated in growth-cone guidance through genetic, biochemical, and pharmacological studies. Adapter proteins containing src homology 2 (SH2) domains and src homology 3 (SH3) domains provide a means of linking guidance signaling through phosphotyrosine to downstream effectors regulating growth-cone motility. The Drosophila adapter, Dreadlocks (Dock), the homolog of mammalian Nck containing three N-terminal SH3 domains and a single SH2 domain, is highly specialized for growth-cone guidance. In this paper, we demonstrate that Dock can couple signals in either an SH2-dependent or an SH2-independent fashion in photoreceptor (R cell) growth cones, and that Dock displays different domain requirements in different neurons.
Medical subject headings
- Axons
- Ganglia, Invertebrate
- Nerve Fibers
- Nerve Tissue Proteins
- Signal Transduction