Steroid-responsive myopathy with deficient chondroitin sulfate C in skeletal muscle connective tissue.
case_report · Level V
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- Record sourced from PubMed, PMID 9484390.
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Abstract
A 71-year-old man developed severe limb, bulbar, and respiratory weakness over 18 months. A muscle biopsy showed only a moderate degree of type 2 atrophy, but immunocytochemistry showed absence of chondroitin sulfate C glycosaminoglycan in the endomysium. Prednisone produced a marked increase in strength. Diffuse loss of endomysial chondroitin sulfate C was a feature of this treatable myopathy with severe weakness, but few pathologic changes.
Medical subject headings
- Chondroitin Sulfates
- Muscle, Skeletal
- Muscular Diseases
- Prednisone
Anatomy
- hand