Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy.
case_series · Level IV
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Abstract
The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.
Medical subject headings
- HIV Infections
- Muscle, Skeletal
- Myopathies, Nemaline