Lhermitte's sign following chemotherapy with docetaxel.

van den Bent, M J; Hilkens, P H; Sillevis Smitt, P A; van Raaij-van den Aarssen, V J; Bontenbal, M; Verweij, J · Neurology · 1998

case_series · Level IV

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Abstract

Specific causes for Lhermitte's sign (LS) in cancer patients are spinal cord compression, radiation therapy to the spinal cord, and cisplatin chemotherapy. We observed a transient LS in five of 87 patients treated with more than two cycles of 100 mg/m2 docetaxel (Taxotere). LS developed either concurrently or after the onset of docetaxel-induced sensory neuropathy, and disappeared after the discontinuation or dose reduction of chemotherapy.

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