Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.

Uchuya, M; Fleury, A; Graus, F; Costagliola, D; Liblau, R; Merle-Beral, H; Théodorou, I; Delattre, J Y · Neurology · 1998

case_control · Level III

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Abstract

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."

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