Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.
case_control · Level III
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Abstract
Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited. T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions. Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment. Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.
Medical subject headings
- Depression