Omeprazole in infants with cimetidine-resistant peptic esophagitis.
case_series · Level IV
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- Record sourced from PubMed, PMID 9506656.
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Abstract
Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.
Medical subject headings
- Anti-Ulcer Agents
- Esophagitis, Peptic
- Omeprazole