The effects of bone resorption inhibitors on the growth plate and proximal tibial metaphysis of rats: clinical implications.
basic_science · Level V
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Abstract
This study investigated the effects of diphosphonates at scalar doses in a high bone turnover structure, namely, the proximal tibial metaphysis of rats. Arrest of bone modeling was represented by cylindrical-shaped metaphyses, increased height of the perichondrial bone bark, and persistence of primary metaphyseal trabeculae; these changes were dose-related. Higher doses of the inhibitors produced extension of the growth plate and arrest of the mineralization process. The dose-related dissociation between the effects on bone resorption and mineralization allows the therapeutic use of this class of drugs.
Medical subject headings
- Bone Resorption
- Calcitonin
- Diphosphonates
- Growth Plate
- Tibia
Anatomy
- tibia