A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix.
case_series · Level IV
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Abstract
Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.
Medical subject headings
- Adenoma
- Chromosomes, Human, Pair 19
- Genes, Tumor Suppressor
- Peutz-Jeghers Syndrome
- Uterine Cervical Neoplasms