Terbinafine hepatotoxicity: case report and review of the literature.
case_report · Level V
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Abstract
We report a patient who developed significant liver dysfunction following therapy with terbinafine. At the end of a 3 1/2-wk course of terbinafine, he developed progressive jaundice and pruritus. His serum bilirubin peaked at 30.9 mg/dl 3 wk after discontinuing terbinafine. A liver biopsy revealed mild to moderate mixed cellular infiltrate in the portal tracts, and hepatocellular and canicular cholestasis. His liver tests normalized 100 days after stopping terbinafine.
Medical subject headings
- Antifungal Agents
- Chemical and Drug Induced Liver Injury
- Naphthalenes