Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?
case_report · Level V
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- Record sourced from PubMed, PMID 9520249.
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Abstract
The treatment of neuropathic pain remains a challenge as it rarely leads to long-term relief of symptoms. We report three patients with chronic neuropathic pain, in whom acute administration of the N-methyl-D-aspartate (NMDA) receptor antagonist amantadine resulted in complete resolution of symptoms, presumably due to termination the central 'wind-up' phenomenon.
Medical subject headings
- Amantadine
- Analgesics, Non-Narcotic
- Pain
- Receptors, N-Methyl-D-Aspartate