Trace alignment and some of its applications.
basic_science · Level V
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Abstract
Extra useful information can be extracted from a DNA chromatogram trace, over that contained in the base-called DNA sequence. Many sequencing applications can benefit from examination of these traces. An algorithm, based on dynamic programming, for aligning a DNA chromatogram to a DNA sequence is described and implemented. Its applications to vector clipping, EST alignment and mutation detection are discussed.
Medical subject headings
- DNA
- Sequence Alignment
- Sequence Analysis, DNA