SNAREpins: minimal machinery for membrane fusion.
basic_science · Level V
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- Record sourced from PubMed, PMID 9529252.
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Abstract
Recombinant v- and t-SNARE proteins reconstituted into separate lipid bilayer vesicles assemble into SNAREpins-SNARE complexes linking two membranes. This leads to spontaneous fusion of the docked membranes at physiological temperature. Docked unfused intermediates can accumulate at lower temperatures and can fuse when brought to physiological temperature. A supply of unassembled v- and t-SNAREs is needed for these intermediates to form, but not for the fusion that follows. These data imply that SNAREpins are the minimal machinery for cellular membrane fusion.
Medical subject headings
- Cell Membrane
- Membrane Proteins
- Vesicular Transport Proteins