Ambulatory activity as an objective and quantifiable measure of nonsteroidal therapy.

Abstract

To quantify any increase in short term spontaneous ambulatory activity resulting from the use of nonsteroidal antiinflammatory drugs (NSAID) in patients with rheumatoid arthritis (RA). Double blind placebo controlled crossover study of 8 women with RA using conventional assessments and the Numact activity monitor. Patients' ambulatory activity was 50% greater during NSAID treatment compared to placebo treatment. Effect size calculated at 0.62, suggesting good sensitivity to change. The increased activity occurred late morning. Spontaneous ambulatory activity is an objective and relevant measure of disability.