Refractory hyperglycemia complicating an evolving connective tissue disease: response to cyclosporine.

Kramer, N; Rosenstein, E D; Schneider, G · J Rheumatol · 1998

case_report · Level V

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Abstract

A 33-year-old woman with longstanding rheumatoid arthritis and Sjögren's syndrome developed type B insulin resistance (diabetes mellitus due to anti-insulin receptor antibodies) simultaneous with the evolution of her rheumatic disease to mixed connective tissue disease. Cyclosporine therapy induced a remission of receptor antibody mediated insulin resistance and controlled clinical manifestations of her systemic lupus erythematosus and dermatomyositis, but had no effect on the sclerodermatous features of her illness.

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