Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
case_report · Level V
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Abstract
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Medical subject headings
- Acidosis, Lactic
- Anti-HIV Agents
- HIV Seropositivity
- Infectious Disease Transmission, Vertical
- Pregnancy Complications, Infectious
- Zidovudine