Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol.
prospective_cohort · Level II
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Abstract
Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure. Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions. In healthy women receiving 2.5 mg norethindrone acetate and 50 microg ethinyl estradiol daily for three consecutive menstrual cycles, concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone. Thus, gabapentin is unlikely to cause contraceptive failure.
Medical subject headings
- Acetates
- Amines
- Anticonvulsants
- Contraceptives, Oral, Synthetic
- Cyclohexanecarboxylic Acids
- Estradiol Congeners
- Ethinyl Estradiol
- Norethindrone
- gamma-Aminobutyric Acid