Fetal tissue typing in anticipation of neonatal heart transplantation.
case_report · Level V
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- Record sourced from PubMed, PMID 9572176.
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Abstract
Hypoplastic left heart syndrome is among the most common major congenital cardiac anomalies. Fetuses with this anomaly survive but require either reconstructive surgery or heart transplantation postnatally. A woman whose fetus was diagnosed with hypoplastic left heart syndrome underwent funipuncture for fetal tissue typing. The fetus then was listed for heart transplantation. Once an ABO-compatible donor heart was procured, the fetus was delivered and immediately underwent transplantation. In candidates for neonatal heart transplantation, fetal tissue typing allows the search for an ABO-compatible donor heart to begin earlier. This approach minimizes the morbidity associated with postnatal waiting and allows transplantation to take place while the neonate is less immunocompetent.
Medical subject headings
- ABO Blood-Group System
- Adult
- Female
- Fetal Blood
- Fetus
- Fetus/immunology
- Heart Transplantation
- Histocompatibility Testing
- Humans
- Hypoplastic Left Heart Syndrome
- Hypoplastic Left Heart Syndrome/diagnosis
- Hypoplastic Left Heart Syndrome/surgery
- Infant, Newborn
- Pregnancy
- Prenatal Diagnosis