Allosteric effects of DNA on transcriptional regulators.
basic_science · Level V
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- Record sourced from PubMed, PMID 9582068.
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Abstract
Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.
Medical subject headings
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Regulatory Sequences, Nucleic Acid
- Transcription Factors
- Transcription, Genetic