A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 9596006.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
Medical subject headings
- Monoamine Oxidase
- Parkinson Disease
- Polymorphism, Genetic
- Smoking