Coupling the folding of homologous proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 9600887.
- Also identified by PMC identifier 34490.
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Abstract
The empirical observation that homologous proteins fold to similar structures is used to enhance the capabilities of an ab initio algorithm to predict protein conformations. A penalty function that forces homologous proteins to look alike is added to the potential and is employed in the coupled energy optimization of several homologous proteins. Significant improvement in the quality of the computed structures (as compared with the computational folding of a single protein) is demonstrated and discussed.
Medical subject headings
- Models, Molecular
- Models, Theoretical
- Protein Folding
- Proteins
- Sequence Homology, Amino Acid