Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure.
prospective_cohort · Level II
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Abstract
We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (< or = 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-1, granulocyte-macrophage colony-stimulating factor, interleukin-1 receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide.
Medical subject headings
- Cytokines
- Cytokines/metabolism
- Female
- Humans
- Infant, Newborn
- Lipid Peroxidation
- Lipid Peroxidation/drug effects
- Male
- Nitric Oxide
- Nitric Oxide/administration & dosage
- Nitric Oxide/adverse effects
- Nitric Oxide/metabolism
- Persistent Fetal Circulation Syndrome
- Persistent Fetal Circulation Syndrome/complications
- Persistent Fetal Circulation Syndrome/drug therapy
- Persistent Fetal Circulation Syndrome/metabolism
- Prospective Studies
- Respiration, Artificial
- Respiratory Distress Syndrome, Newborn
- Respiratory Distress Syndrome, Newborn/etiology
- Respiratory Distress Syndrome, Newborn/metabolism
- Tyrosine
- Tyrosine/analogs & derivatives
- Tyrosine/analysis