Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease.
case_report · Level V
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Abstract
A 5-year-old boy with chronic granulomatous disease (CGD) was treated with amphotericin B for an invasive pulmonary Aspergillus nidulans infection. The infection progressed during 6 wk of treatment despite the addition of interferon-gamma (IFN-gamma), filgrastim, and transfusions with donor granulocytes. Treatment with a novel antifungal triazole, voriconazole, resulted in an excellent clinical response.
Medical subject headings
- Antifungal Agents
- Aspergillosis
- Aspergillus nidulans
- Granulomatous Disease, Chronic
- Lung Diseases, Fungal
- Pyrimidines
- Triazoles