The effect of ketamine pretreatment on propofol injection pain in 100 women.
rct · Level II
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Abstract
A controlled, randomised double-blind study was performed to compare the prior intravenous administration of ketamine 10 mg (1 ml) or 0.9% saline (1 ml) on propofol injection pain. One hundred patients of ASA status 1 or 2 presenting for gynaecological surgery were studied. Following an initial 5-ml bolus of propofol into a dorsal hand vein, 30 s after the treatment, 84% of the saline control patients experienced mild or severe pain compared to 26% of those who were given ketamine pretreatment (p < 0.05).
Medical subject headings
- Anesthetics, Dissociative
- Anesthetics, Intravenous
- Ketamine
- Pain
- Propofol