Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine.

Ronchi, F; Cecchi, P; Falcioni, F; Marsciani, A; Minak, G; Muratori, G; Tazzari, P L; Beverini, S · Arch Dis Child · 1998

case_report · Level V

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Abstract

Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.

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