Transcription regulatory region analysis using signal detection and fuzzy clustering.
basic_science · Level V
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Abstract
Presently available programs for the recognition of potential transcription factor binding sites in genomic sequences generally yield a huge amount of output. These output lists have to be filtered to obtain biologically significant elements, which is highly laborious work to be done manually. We developed a strategy for systematic verification and improvement of the underlying profiles, and for their contextual analysis by a fuzzy clustering approach using non-redundant libraries of search profiles as a prerequisite. The tools mentioned in the paper are available upon request. ewi@gbf.de
Medical subject headings
- Fuzzy Logic
- Regulatory Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Signal Processing, Computer-Assisted
- Transcription, Genetic