Chromatin components as part of a putative transcriptional repressing complex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 9636147.
- Also identified by PMC identifier 22604.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Drosophila HMG1-like protein DSP1 was identified by its ability to inhibit the transcriptional activating function of Dorsal in a promoter-specific fashion in yeast. We show here that DSP1 as well as its mammalian homolog hHMG2 bind to the mammalian protein SP100B and that SP100B in turn binds to human homologs of HP1. The latter is a Drosophila protein that is involved in transcriptional silencing. Each of these proteins represses transcription when tethered to DNA in mammalian cells. These results suggest how heterochromatin proteins might be recruited to specific sites on DNA with resultant specific effects on gene expression.
Medical subject headings
- Antigens, Nuclear
- Chromatin
- Drosophila Proteins
- High Mobility Group Proteins
- Repressor Proteins
- Transcription Factors
- Transcription, Genetic