KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.
basic_science · Level V
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- Record sourced from PubMed, PMID 9636207.
- Also identified by PMC identifier 22716.
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Abstract
The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.
Medical subject headings
- Ataxia Telangiectasia
- Carrier Proteins
- DNA Damage
- DNA Helicases
- DNA Repair
- Leucine Zippers
- Tumor Suppressor Protein p53