Normal serum iron and ferritin concentrations in patients with Friedreich's ataxia.
case_series · Level IV
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- Record sourced from PubMed, PMID 9667602.
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Abstract
Friedreich's ataxia (FRDA) is caused by point mutations or trinucleotide repeat expansions in both alleles of the gene encoding frataxin. Studies of frataxin homologues in lower eukaryotes suggest that mitochondrial iron accumulation may underlie the pathophysiology of FRDA. To evaluate the possible role of iron-chelation therapy for FRDA, we measured serum iron and ferritin concentrations in 10 FRDA patients. The measurements were within normal limits, suggesting that iron-chelation therapy for FRDA may be problematic.
Medical subject headings
- Ferritins
- Friedreich Ataxia
- Iron