Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 9671776.
- Also identified by PMC identifier 21174.
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Abstract
Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
Medical subject headings
- Islets of Langerhans
- Pancreatic Diseases
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors