Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis.
case_report · Level V
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Abstract
We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.
Medical subject headings
- Autoantibodies
- Encephalitis
- Epilepsia Partialis Continua
- Immunoglobulin G