A viral mechanism for inhibition of the cellular phosphatase calcineurin.
basic_science · Level V
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Abstract
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
Medical subject headings
- African Swine Fever Virus
- Calcineurin Inhibitors
- DNA-Binding Proteins
- Macrophages, Alveolar
- Nuclear Proteins
- Transcription Factors
- Transcription, Genetic
- Viral Proteins