Cardiopulmonary bypass in a gravid patient: perioperative changes in endothelin levels.

Zellner, J L; Kribbs, S B; Dorman, B H; Spinale, F G · Ann Thorac Surg · 1998

case_report · Level V

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Abstract

Transient elevations of the potent vasoconstrictive peptide endothelin have been reported to occur with the institution of cardiopulmonary bypass. We measured plasma endothelin levels in a 24-year-old gravid patient undergoing a mitral valve replacement operation. Plasma endothelin levels increased by more than 250% in the first 24 hours postoperatively and remained elevated above baseline values at 36 hours postoperatively.

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