The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
basic_science · Level V
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Abstract
The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.
Medical subject headings
- Carrier Proteins
- Cell Cycle Proteins
- DNA-Binding Proteins
- Nuclear Proteins
- Protein Serine-Threonine Kinases
- Proteins
- Proto-Oncogene Proteins c-myc
- Transcription Factors