Combined schedule of 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal vaccine in children and young adults with sickle cell disease.
rct · Level II
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Abstract
We compared the immunogenicity of 7-valent pneumococcal-conjugate vaccine plus 23-valent pneumococcal vaccine to immunization with 23-valent vaccine only in individuals > or = 2 years of age with sickle cell disease. IgG pneumococcal antibody concentrations were higher in the combined schedule group with no increase in side effects observed after immunization with 23-valent vaccine.
Medical subject headings
- Anemia, Sickle Cell
- Antibodies, Bacterial
- Bacterial Vaccines
- Streptococcus pneumoniae
- Vaccines, Conjugate