Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia.
case_report · Level V
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- Record sourced from PubMed, PMID 9726762.
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Abstract
The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil. Despite a warning by the manufacturer, only one report of this interaction has been published in the literature. This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.
Medical subject headings
- Anticoagulants
- Gemfibrozil
- Hypolipidemic Agents
- Hypoprothrombinemias
- Warfarin