Segregation of transcription and replication sites into higher order domains.
Level V
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- Record sourced from PubMed, PMID 9727975.
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Abstract
Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.
Medical subject headings
- Cell Nucleus
- DNA Replication
- Genome
- Transcription, Genetic