A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.
basic_science · Level V
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Abstract
Caveolin-1 functions as a membrane adaptor to link the integrin alpha subunit to the tyrosine kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc. Shc is subsequently phosphorylated at tyrosine 317 and recruits Grb2. This sequence of events is necessary to couple integrins to the Ras-ERK pathway and promote cell cycle progression. These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Caveolins
- Integrins
- Membrane Proteins
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Signal Transduction