Familial amyotrophic lateral sclerosis with widespread vacuolation and hyaline inclusions.
case_report · Level V
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Abstract
This report presents a familial amyotrophic lateral sclerosis (FALS) patient with widespread vacuoles and hyaline inclusions strongly immunostained with the anti-superoxide dismutase (SOD1) antibody. The overall pathologic similarity between our non-SOD1-linked FALS patient and transgenic mice expressing a mutated human SOD1 gene suggests that common pathogenetic mechanisms other than an SOD1 mutation exist in the development of these diseases.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Inclusion Bodies