Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.
case_series · Level IV
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Abstract
In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.
Medical subject headings
- Iron
- Lewy Bodies
- Nerve Tissue Proteins
- Neurodegenerative Diseases
- Pantothenate Kinase-Associated Neurodegeneration