Proton magnetic resonance spectroscopy in primary blepharospasm.

Federico, F; Simone, I L; Lucivero, V; Defazio, G; De Salvia, R; Mezzapesa, D M; Petruzzellis, M; Tortorella, C et al. · Neurology · 1998

cross_sectional · Level IV

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Abstract

Single-volume proton magnetic resonance spectroscopy, localized to basal ganglia, was carried out in 10 patients with primary blepharospasm (PB) to assess the levels of N-acetyl aspartate (NAA), creatine-phosphocreatine, and choline-containing compounds. NAA was reduced significantly in patients compared with control subjects. This result suggests a striatal neuronal loss in PB.

Medical subject headings