Brain infarction following 5-fluorouracil and cisplatin therapy.
case_series · Level IV
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- Record sourced from PubMed, PMID 9748055.
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Abstract
Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patient; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Cerebral Infarction
- Cisplatin
- Fluorouracil